2018 Undergraduate Exhibition

Title Presenter Abstract Faculty Sponsor Numbersort descending
Relational Turning Between Cancer Patients and Their Spouses Katlyn Marie Reynolds The purpose of this study is to understand relational turning points (RTPs) between cancer patients and their spouses over the course of the illness. A qualitative design was used to explore the lived experiences of this relationship following a diagnosis of cancer. This sample included 7 married couples. RTPs occurred at the time of diagnosis when couples experienced stress and strain and at the time of remission, when most couples reported their relationship grew stronger. Raymond Petren 183
Partisan Bias in Electoral Conflict: Tanzania's Kawe Constituency Seamus Patrick Wagner

This work examines what factors influence varied perceptions of electoral conflict using a case study in Tanzania. The 2015 general elections in Tanzania, some constituencies experienced electoral conflict. Using an original survey developed in conjunction with graduate students at the University of Dar es Salaam, this paper tests perceptions of violence in Kawe, a constituency in the heart of Dar es Salaam that experienced conflict during the 2015 general elections.

Elizabeth Carlson 184
The influence of family and friends have on minorities cycling Jacqueline Netro Beltran  Despite cycling having multiple benefits, minority cycling rates are low. The study examined roles family/friends play with respect to supporting/hindering cycling among minorities  An online survey analyzed aspects of cycling involvement. Responses coded and themes identified using NVivo.   Participants were African Americans. Two themes emerged; support from family/friends;  the relationship between the cyclist and family/friends changed in a positive manner.    Findings provide insight of the importance family/friends have on minority cycling participation.   Melissa Bopp 185
Mechanisms and Applications of Viruses and Small Molecules for Brain Repair Caitlin Marie Komm and Heli Patel

Many neurological disorders are characterized by loss of different types of neurons. Reprogramming is a process in which glial cells in the brain are changed into functional neurons. Two aspects are reprograming by small molecules to induce the Gabaergic Phenotype and reprogramming using viruses that encode transcription factors to induce a dopaminergic phenotype. A third aspect is exploring the mechanism by which NeuroD1, a transcription factor, reprograms glial cells into functional Glutamatergic neurons.

Maria Krasilnikova 186
Heavy Metal Concentrations: Spatial Variability and Environmental Risks in the Peruvian Andes Evan S Plumridge Climate change and glacial recession have introduced a new pathway for metals to enter the high altitude wetlands of Ausangate, Peru. When newly exposed rock comes in contact with precipitation and meltwater, metals such as Aluminum, Cadmium, Cobalt, Copper, Iron, Lead, Nickel, and Zinc can be mobilized and transported down the watershed and into surrounding wetlands and streams. This represents a potential new source of metals that may impact human health and ecosystem services. Mike Nassry 187
Vortex Core Dynamics in a Swirling Jet Near Vortex Breakdown Sean Clees

The dynamics of a swirling jet are investigated at swirl numbers in the range of the critical swirl number for vortex breakdown (VB). VB, a bifurcation in the structure of a swirling jet, results in a recirculation region forming along the centerline of the jet. Investigation of time-averaged velocity measurements leads to the identification of three flow regimes. Velocity fields in these regimes are analyzed to characterize jet dynamics and identify a precessing vortex core.

Jacqueline O'Connor 188
Yeast 2-hybrid screening for novel interactors of Shrm3, a protein involved in neural tube morphogenesis. Trevor Frank Tranchina Shroom (Shrm) is a highly conserved family of proteins that are defined by the conservation of actin and Rho kinase binding domains. Shroom family proteins have been implicated in the development of the vertebrate ear, kidney, and in brain connectivity. Little is known about what activates Shrm3 function or localization. To better understand these processes we aimed to find novel protein interactors of Shrm3. The screens returned a number of novel interactors. Jessica Petko 189
Habitable Planets: Do not disturb, life may be in progress Michael S Penwarden

Planets within a solar system’s “habitable zone” have the right temperatures to support ingredients for life. We assessed if habitable zone planets would continue to be habitable in the presence of other planets. We simulated planets in different solar systems for millions of years; after very long periods of time other planets cause disturbances which may adversely affect their ability to support life. Global temperatures are very sensitive to the orbit of the planet.

Rebekah Dawson 19
Understanding the Reciprocal Relationship Between Interpersonal Behaviors and Autonomic Nervous System Functioning in Patients with Borderline Personality Disorder Mckayla Bradford Mawn The aim was to characterize the role of sympathetic nervous system (SNS) functioning in interpersonal dysfunction in those with Borderline Personality Disorder (BPD). It was hypothesized that patients with BPD would experience greater SNS activation during interpersonal interactions. 110 romantic couples (one partner was selected for psychopathology) discussed the greatest disagreement in their relationship for 10 minutes while skin conductance data and behavioral states were coded. Results indicate that BPD patients experienced decreased SNS activation. Michael Hallquist 190
USING BILINGUALISM AS A TOOL TO STUDY RECOGNITION MEMORY FOR GRAMMAR AND MEANING Aliza N Winneg To reconcile an ongoing debate to whether the retention of form takes precedence over the retention of meaning in memory, an eye-tracking reading study was conducted on bilingual participants at the University of Puerto Rico. Participants read unilingual Spanish and codeswitched sentences and answered comprehension questions, always in unilingual sentences.  Results suggest that form of the target noun is retained and results in interference. However, a simple math problem was enough for interference to disappear. Giuli Dussias 191
Thermo-electric Field Assisted Sintering of U.S. Bronze Christian D Muth Research focused on determining the effects of thermo-electric field assisted sintering of a bronze material. The sintering will occur using an Ultra-flex HS-4 induction heater and simultaneously passing of a current through the sample to the point of sintering. Following, the microstructural characteristics and mechanical properties of the sintered samples will be compared with that of a conventional oven style sintering process. Daudi Waryoba 192
A Review of the Techniques for the Application of Filler Metal in the Sinter-Brazing Process Matthew E Lingle The most common type of filler metal that is used in the sinter-brazing process is a 40% Copper/ 40% Nickle material. Filler metal pellets, paste, and paint are all tested in this experiment. The application techniques will be reviewed using an iron based material that is molded to a 7.0 g/cc density and sintered in a Carbon Monoxide containing atmosphere. The test specimens will be tensile tested lap joints. Daudi Waryoba 193
How Chemistry Effects the Rheology of Powder Feedstock for Directed Energy Deposition Cory David Jamieson Analyzing chemistry of powders and comparing the traditional and dynamic flow properties will help predict a powders performance in environments encountered when applied to additive manufacturing processes and will also help to establish the fundamental understanding of process-structure-property relationships. By understanding what makes an ideal powder will allow for the production of future materials with similar properties that provide the highest quality product produced from AM methods.     stephen feldbaure 194
Determining the role of mthl3 in Dendrite Regeneration Karina Grullon-Perez

Neurons are polarized cells that are susceptible to injury due to neurotoxicity from stroke, seizure or traumatic brain injury. Previous work has demonstrated that the DLK signaling pathway, while required for axon regeneration, is dispensable for dendrite regeneration. mthl3, a member of the methuselah/methuselah-like family of GPCR, was identified as a gene required for dendrite regeneration in a functional genomics screen. The goal is to determine the specificity of mthl3 in dendrite development and regeneration.

Melissa Rolls 195
The Effectiveness of Extracurricular Programs in Determining Choice of Academic Major for Young Women Emmeline Michelle Evans

Extracurricular STEM programs for girls in middle and high school are rapidly gaining visibility and popularity. However, research into how effective these programs are in encouraging girls to enter STEM fields is limited to the programs’ own internal reports. Through surveys and interviews of Penn State undergraduates who participated in these programs, I seek to determine how effective they are at encouraging girls to pursue STEM degrees as undergraduates and how they could be improved.

Dr. Christopher McComb 196
The Potential of Coating Polyurethane with ‘Self-like’ Molecules to Reduce the Host Response to Implanted Medical Devices Sheherbano Hussain, Jimmy Hadid and Zoha Babar

Macrophages, cells of the immune system, play a pivotal role in the host inflammatory response by attacking foreign materials not seen as ‘self.’  Implanted biomedical devices made of polyurethane are not identified as ‘self.’  The potential of coating polyurethane with ‘self-like’ molecules to reduce or prevent the host response from attacking such devices propelled this research. The reduction of macrophage adherence to polyurethane films coated with palmitoleic acid and bovine serum albumin will be presented.

Dr. Jacqueline McLaughlin 197
Low Temperature Plasma Treatment and Its Effects on Titanium Tacie Savannah Telesky Low temperature plasma (LTP) treatment of biomaterials has been suspected to enhance biocompatibility and exhibit sterilization potential. In collaboration with an implant company, our efforts involve treating samples with a LTP jet. Changes in the surface morphology and chemical composition from LTP will then be investigated. If data provides confirmatory evidence of a cleaning effect or enhanced biocompatibility, LTP treatments could surface as a fast and cost-effective way to improve industries’ current biomaterials.   Sean Knecht 198
Women's Legislative Representation in Africa Jennifer A Heckman What explains variation in the level of women’s legislative representation in Africa? This paper expands on previous studies to examine the interaction between demand-side and supply-side factors in the analyses. In this paper, I rectify these limitations in the existing literature by examining how institutional, economic, cultural, and international factors influence the supply of, and demand for, women’s representation in Africa by using a new dataset. Matthew Golder 199
Development of a Micro-Particle Image Velocimetry Platform to Study Thrombosis In Vitro Tice Ryan Harkins

Micro-particle image velocimetry (μPIV) provides the ability to quantitatively measure microflow alongside thrombus development. Using a μPIV platform, we aim to capture the real time in vitro formation of a thrombus and better understand the micro-scale factors related to thrombus growth. Preliminary data support the μPIV system's ability to quantitatively measure flow. Results were compared to a computer COMSOL model under the same flow conditions. The experimental data validated the computational model.

Keefe Manning 20
The Politics of Arctic Sea Ice Loss and the Law of the Sea Emma S A Behr This is a qualitative thesis comprised of comparative case studies (the United States, Canada, and Denmark) exploring the reasons why the United States is the only country of the eight Arctic nations that has not ratified the United Nations International Law of the Sea Treaty. The results show that the main factors influencing a country's likelihood of treaty ratification are the presence of nonrenewable energy business interest groups, regime type, and public opinion. Xun Cao 200
The "Not-So-Common" European Asylum System: Determinants of Asylum Policy in the EU28 2008-2016 Alice Elizabeth Greider This paper seeks to examine the national determinants of asylum policy as a way to better understand the failures of the Common European Asylum System. Using a multivariate regression analysis, I gauge the importance of economic, political, popular opinion, and capacity factors in shaping asylum policy from 2008 to 2016. Contrary to my predictions, I find that issue salience and geographic proximity matter more for asylum policy than do other political or structural factors. Sona Golder 201
Advanced Turbine Measurement System Design for Rotating Instrumentation Ashley Nicole Castell

The START Laboratory is a research facility housing a test turbine engine where advanced heat flux sensors need to be implemented to gather more test data and continue experiments. In order to implement these sensors into the continuous-duration turbine, unique methods such as the use of slip rings and custom designed couplings will be used to allow these parts to function within the constraints of the turbine.

Reid Berdanier 202
Inventory Management for Monarch HVAC Service Bijesh O Huerta I devised an implementation plan for an inventory management system for my father's company, Monarch HVAC Service. The scope of the plan is to improve productivity and save money. If all goes well, I hope to continue to expand further business processes.  Paul Bart 203
Bilayer Formation on Protocells Alex Grigas Coacervates are a type of liquid-liquid phase separation that have protocellular properties. We characterized the interactions between different coacervate systems at different charge ratios and different liposome systems in order to investigate the possibility of bilayer formation on the surface of coacervates. Several of our systems achieved liposome assembly at the interface, but continuous bilayer formation was not observed. Chris Keating 204
Boots on the Ground: Examining the Effects of Militarized Agricultural Aid on Rural Afghanistan Olivia Rae Richart The purpose of this research is to examine the effectiveness of Agricultural Development Teams through an analysis of their impact on social, economic, and infrastructural dynamics in rural Afghanistan. The facets which are explored include outreach methods, funding sources, troop readiness, and interdisciplinary approaches. Through this, I hope to discover the highlight the ultimate effectiveness of militarized agricultural aid provided by the United States Army and Air Force. Noel Habashy 205
Bovine Mammary Glands Use Leaky Basolaterial Cell Boarder to Accommodate Essential IgG1 Transportation During Colostrogenesis Jacqueline Kay O'Donnell

Colostrum is a thick form of milk that bovine produce prior to parturition , which contains high concentration of IgG. E-Cadherin is a adhesive junction between the epithelial cells in the mammary gland. In this study we used IHC to analyze changes of E-Cadherin during the colostrogenesis. The results showed that the junctions became leaky to facilitate the transportation of colostrum.

Gang Ning 206
Environmental stress on chromatin/protein binding in yeast Olivia Muly Every cell regularly reads its genetic code to produce mRNA in a process called transcription, with the aim of ultimately producing thousands of proteins. Eukaryotic organisms use a system of activator and repressor proteins to modulate transcription. The goal of this research is to understand how genes are regulated by exposure to environmental stress and subsequent characterization of protein/DNA interactions genome-wide through ChIP-exo technology. Frank Pugh 207
Determining zebrafish preference of food or novel object presentation through behavioral observations Alisha Pushinsky

Unpredictable captive environments can induce stress, which can negatively impact animal welfare. Our objective was to determine zebrafish preference between a food and object reward. These preliminary results would be utilized in future experimentation to determine if fish can associate a preferred stimulus with a specific caregiver, to re-introduce predictability within their environment. We found that fish became more cohesive, coordinated and displayed less aggression when interacting with food, than a novel object.

Victoria Braithwaite 208
Investigating Sensory and Motor Differences in Varying Force Output in Young Adults with and without ADHD Jacqueline Rose Tucker The overarching goal was to determine whether fingertip forces are related to somatosensation in adults with and without Attention Deficit/Hyperactivity Disorder (ADHD). This work is important because it could improve our understanding of the neurobiology of ADHD. Existing literature suggests adults with ADHD may have different sensory processing patterns. The results suggest that the clinical somatosensory measures used may not have enough resolution to detect subtle, yet important, differences in adults with and without ADHD.  Kristina Neely 209
APP for medical instrument device AnyMDx Tianyi Liu

This article related to the process of developing A Mobile Phone APP for medical instrument. The main function of the APP is offering the connectivity to our portable molecular diagnostic system. It will allow the control command and data communication between the portable AnyMDx and the smartphone. With powerful computation ability associated with the smartphone, a database and cloud based results aggregation system can be used for malaria elimination effort.

Weihua Guan 21
An Evaluation of Slides Prepared for Cervical Anomaly for Use in Missing Person Cases Mackenzie Pickford In Forensic Science cases, sometimes a female victim goes missing. DNA profiles obtained from bloodstains or cigarette butts retrieved from the crime scene cannot be compared to her profile due to lack of reference samples. In these cases, specimens such as routinely preserved Papanicolaou test slides can be used as the reference sample (intimate source). In this research, complete DNA profiles were generated from stained Papanicolaou smear slides using direct amplification and extracted DNA Reena Roy 210
Sensitivity Analysis of Wearable Textiles for ECG Sensing Wenxin Tong The quality of textile-based ECG sensing is sensitive to external factors (such as sensor placement and contact pressure). There is an urgent need to investigate how the quality of ECG sensing is influenced by these factors and improve the design of wearable textiles. Hui Yang 211
Low Temperature Plasma Treatment of Bacteria to Combat Infective Endocarditis Lindsey Cicchino

Endocarditis is a bacterial infection that has a high mortality rate because the molecules of antibiotics are too large to penetrate the biofilm of the bacteria. Low temperature plasma (LTP), currently used to sterilize medical equipment, will be created by running 30,000V through two electrodes over a 20 nanosecond time span in either water, saline, fetal bovine serum, and eventually human blood.

Dr. Sean Knecht 212
Elucidation of the Mechanism of Fom3, a Cobalamin Dependent Radical SAM Enzyme Roy Wang Recent studies have revealed that Fom3, a cobalamin-dependent radical S-adenosylmethionine enzyme, catalyzes the methylation of carbon 2 of cytidylyl-2-hydroxyethylphosphonate during the biosynthesis of fosfomycin, a broad spectrum antibacterial agent; however, the mechanism by which Fom3 catalyzes this reaction remains elusive. Herein, we demonstrate the first successful isolation of Fom3 with both its iron-sulfur and cobalamin cofactors bound. Furthermore, our studies provide key mechanistic insight for a number of steps in the Fom3 reaction. Squire Booker 213
Singular "they": Online and offline interpretation effects among L1 and L2 speakers Neil C Shook We investigate how L1 and L2 English speakers utilize competing number cues when interpreting singular they. Participants read sentences containing referential (that jogger) or nonreferential (a jogger) subjects, which were referred to using singular (he/she) or plural (they) pronouns. When interpreting the subject’s number, L1 speakers exhibited an interaction between pronoun type and referential/nonreferential subjects. L2 speakers showed no interaction, suggesting that they may be less able to integrate multiple, conflicting cues than L1 speakers. Carrie Jackson 214
Development and Optimization of a Cell Free Terminator Assay for Viral RNA Polymerases Phillip Ryan Clauer Riboswitches can detect small molecules and serve as sensitive biological diagnostics. However, engineering riboswitches for use in diagnostic applications requires the design of genetic terminators compatible with viral polymerases. We report on an in vitro assay using cell-free protein synthesis lysates capable of quantifying termination efficiency to screen terminator candidates. We also demonstrate our assay measurements were consistent with in vivo results and that in vitro conditions can be optimized to dramatically increase terminator efficiency. Julius Lucks 215
Investigation of Humanitarian Aid Effectiveness In the Water Supply and Sanitation (WSS) Sectors Andrew Pannone

In today’s world of finite humanitarian aid finances, it is important to ask - “Is foreign aid actually effective?” Many scholars have sought answers to this question using econometric and political science methodologies.  However, economic and political indicators cannot paint the full picture, so in order to broaden this inquiry, we use sustainable development indicators in the WSS sectors as a basis for analysis.  We utilize data gathered from AidData, the UN, and the Worldbank.

Dr. Caitlin Grady 216
The Effects of NGOs and Corporate Influence on International Development – A Comparative Literature Review Kurtis Miller International development focuses on improving livelihoods across the globe. This development goal is met through economic stimulation, health and nutrition improvement, and gender equity among other criteria. There are many entities, which fall into three categories, influencing the realm of international development. Those categories are: governmental, NGO, or industry. The effects of NGOs and industry activity will be analyzed as a literature review and a conclusion about the merits of each will be discussed. Noel Habashy 217
Sexual Assault and Universities in Pennsylvania Counties Leah Jane Martin

The research I am working on looks at Pennsylvania counties and the presence of sexual assault and rape, measured by PCAR (Pennsylvania Coalition Against Rape) and UCR (Uniform Crime Report), and how that rate correlates with universities in each county. The variables measured will include university enrollment profile of undergraduates and graduates, type of institution (such as public or private), and if the institution is religiously based or not. 

Dr. Barry Ruback 218
Bacillus strains used as a Biological Control for Trichoderma aggressivum aggressivum Melissa Mercado Trichoderma aggressivum aggressivum (Ta2), the causal agent of green mold, inhibits mycelium growth of the Agarcius bisporus mushroom which leads to severe or complete crop loss. Bacillus spp. have been known to show a strong inhibition to Ta2. Bacillus spp., isolated from compost, were screened for inhibition against Ta2. Transposon mutagenesis was performed on Bacillus strains to identify the genes responsible for the inhibition of Ta2. John Pecchia 219
Investigation of Polymer Microneedles in the Delivery of Protein Drugs David Kauffman

Drug delivery methods often suffer from problems ranging from pain and patient noncompliance to reduced drug bioactivity. A series of in-vitro assessments were performed to determine the mechanical strength, insertion ability, encapsulation efficiency, and bioactivity of polymer microneedles containing the model protein VEGF. In-vivo assessments were performed using live mice. The ability to control the release of bioactive proteins through the skin may provide revolutionary new treatments for a range of different pathologies.

Yong Wang 22
Studying Driving Styles of Autonomous Vehicles Aaron Meier

Autonomous vehicle systems have been a topic of interest, as they can reduce vehicular injuries and fatalities. The driving style of the autonomous vehicle and the driver needs to be taken into account when designing such a system. This experiment explores how different driving styles (aggressive vs. defensive) affect how they interact with the autonomous vehicle. This research will add vital findings to the AV space allowing for the design of an autonomous vehicle.

Dr. Yiqi Zhang 220
Evolutionary Computation Applied to a Spacecraft Orbital Maneuver John Drury Evolutionary computation (EC) is an alternate form of technical problem-solving that uses biologically-inspired algorithms to predict optimized solutions. In aerospace engineering, minimizing the amount of fuel needed to reach a certain orbit is very important so the weight of a rocket can be reduced. By comparing the solution produced using the EC algorithms to the known solution of an orbit transfer problem, the algorithms can be refined for accuracy and applied to other spacecraft maneuvers. Brad Sottile 221
Competing approaches to Mexican gastronomic heritage preservation Eva L Bonta Drawing on ethnographic research in Mexico, this paper analyzes the perspectives of chefs, cooks, business owners, and farmers, as well as the Pueblo Coca de Mezcala cultural movement and the UNESCO Intangible Cultural Heritage designation, to examine the different ways traditional foods are valued in Mexico. The results shed light on competing responses to the effects of globalization on Mexican cuisine; however, meaningful linkages are present and are worth expanding upon further. Bronwen Powell 222
The Effect of Non-Traditional Film Cooling Hole Shapes on Cooling Effectiveness Emily J Sun Film cooling is a mechanism by which some of the internal cooling flow is allowed to flow over the surface of the airfoil of a turbine blade. This cooling mechanism is necessary because of the high firing temperature of engines in the pursuit of high efficiency. In order to explore the effects of the complex film cooling geometries, various film cooling hole geometries will be designed, tested, and evaluated based on film cooling effectiveness. Stephen Lynch 223
PHOTOACOUSTIC TOMOGRAPHY PAT Mahima Divyeshbhai Kania

We strive to find the ultimate lowest concentration of absorber that can be imaged at any given depth.  We came up with different kinds of tissue phantom recipes that can mimic human breast tissue best manner. The tissue phantoms are made of varied densities to help perform tomography on the densest and thickest human breast tissues. Diagnosing a cancer at its efficiently early stages of development  can decrease the mortality rate significantly.

Dr. Sean Knecht 224
The evaluation of using low-cost particle sensors in residential microenvironments Taylor Guelich Airborne particulate matter (PM 10 and PM 2.5) has been recognized as one of the leading causes to an increase in adverse biological reactions including asthma. This project evaluates the use of Alphasense OPC-N2 low-cost particle sensor to identify PM 10 and PM 2.5 exposure levels to occupants in residential building microenvironments.  Four activities are evaluated at steady state and when a change is introduced to monitor the indoor air quality. Donghyun Rim 225
Characterizing IRE1a Dependent Leukocyte Recruitment Following UV Irradiation Stephen Daniel Worrell

The basis of my project has been doing a general characterization of an ER stress gene, IRE1a, and its role in inflammatory signaling following UV irradiation. By using both cultured cells and in vivo experiments that have a non functional form of IRE1a, we are able to investigate any significant differences between the knockout and the wild type control model in terms of inflammatory signaling and recruitment.

Dr. Adam Glick 226
Anemia and insomnia: a cross-sectional study and a meta-analysis Samantha N Neumann Recent studies have investigated genes associated with insomnia complaints. We examined whether adults with anemia have higher odds of having insomnia in a cross-sectional study and a meta-analysis. The cross-sectional study included 11,040 Chinese adults who participated in an ongoing cohort, the Kailuan Study. The association between anemia and insomnia was assessed using a logistic regression model. Presence of anemia was significantly associated with higher likelihood of having insomnia. Xiang Gao 227
Localization Team Matthew Keegan

I, along with three other lab members (Maddie, Phil, and Katelyn) will be composing a presentation comprising our recent research on the localization of related proteins in Drosophila dendrites.

Dr. Melissa Rolls 228

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