2022 Undergraduate Exhibition

Title Presenter Abstract Faculty Sponsor Number
Protein aggregation in Lung cancer and COPD Emmanuella Ajenu

In this work, we study protein aggregation due to tobacco smoke in lung cancer cells that can lead to COPD and lung cancer. We use the RT-PCR method to determine which pathways are involved in protein aggregation and autophagy using lung cancer cell line A549. We discovered the increase of some chaperones and proteins involved in autophagy with more prolonged smoke exposure.

Maria Krasilnikova 16895
Punitive Attitudes Toward Sex Offenders: Does Offender Sex Matter? Tyler Frye, Rachel Kosaka and Alicia C. Williams

Little research has explored bias associated with sex offenders. To help fill this gap in the literature, this research isolates correlates of gender-based bias in the sentencing of sexual perpetrators. Using data from a nationally representative sample of 1,000+ Americans, this study employed a vignette research design to assess potential bias in jury decision-making. This study expands our previous results from a small college pilot study and a sample of Pennsylvanian residents.

Nathan Kruis 16287
Purpose of the Smooth Endoplasmic Reticulum in Axon Regeneration after Injury Emily McNaughton

Injury to most neurons resulting in damage to the axon causes lifelong nerve damage. However, peripheral neurons regenerate their axons after injury and could reveal potential treatments for nerve damage. Previous research revealed the smooth endoplasmic reticulum (SER) plays a vital, but unknown role in axon regeneration after injury. My research studies the purpose of the SER in axon regeneration, investigating its role in calcium storage and release through the calcium channel, Ryanodine receptor.

Melissa Rolls 16724
Quantification of bioactive ganoderic acids in two wild mushroom species from Pennsylvania Blaise Sava

Reishi mushrooms have been esteemed by traditional Asian medicine for millennia. Clinical studies suggest they may help treat cancer and other disease. Ganoderma applanatum and G. tsugae are locally occurring relatives of reishi. Though routinely foraged, the chemical makeup of wild specimens is unknown. Mushrooms were collected from sites across Pennsylvania, and their mycochemicals were extracted. In the coming weeks, ganoderic acids A and B will be quantified for final analysis via HP-LC.

Joshua Lambert 17057
Quantitative Modeling of Calcium and Strontium isotope cycles to the Ocean to predict responses to flux perturbations Joshua Karas

The calcium isotope (44Ca/40Ca), radiogenic strontium isotope (87Sr/86Sr), and stable strontium isotope (88Sr/86Sr) systems have been utilized to evaluate changes in mass fluxes during environmental perturbations. These systems can react in unique ways, and a quantitative model showing these changes has yet to be produced. To better understand these interactions, we have created a box model using modern and Cretaceous values for input and output fluxes for 44Ca/40Ca (δ44Ca), 87Sr/86Sr, and 88Sr/86Sr (δ88Sr).

Kimberly Lau 17048
Quantitatively Understanding The Phenomenon of Spreading Depression Tanner Sherry

Spreading depression is a neurophysiological phenomenon characterized by abrupt changes in transmembrane ion gradients and sustained inactivation of neurons. One physiological phenomena that can initiate or result from SD is local cell swelling which is accompanied by a decrease in extracellular space (ECS). The goal is to develop and implement an impedance-based method that will enable the investigation of the causal role of ECS dynamics in initiating SD in different spontaneous seizure and SD dynamics.

Bruce Gluckman 16897
Rapid Detection and Identification of Microplastics using Nile Red AnQi Chen

Micro-plastics has become one of concern in recent years due to its contamination on the environment and the risk involved where organisms could be potentially ingesting it on a daily basis. By evaluating the relationship of Nile Red with the nano- and micro-plastics due to their differences in composition, a method to distinguish between the different nano- and micro-plastics via fluorescence labeling using the Nile Red can be developed.

Dan Sykes 16656
Regulation of sacX expression by SacY and NusG Tejas Wein

Transcription in Bacillus subtilis is regulated at initiation, elongation, and termination. During elongation, activity of RNA polymerase is defined by pausing events stimulated by nucleic acid or protein signals. In antitermination regulatory mechanisms, pausing allows time for protein factors to bind and stabilize secondary structures in the nascent transcript, preventing termination of transcription elongation. In the sacX leader, a pause site mediated by protein factor NusG allows protein factor SacY to bind, allowing transcript readthrough.

Paul Babitzke 17134
Relations of Temperament Dimensions to Children’s Strategy Use in a Novel Situation Mathilde Scarlata

The present study investigated hypotheses predicting that individual temperament dimensions are related to the extent to which children engage cognitive resources in a novel, fear-inducing context. Results show that higher mother-reported child Surgency is associated with children’s higher levels of cognitive engagement. Negative Affectivity is not related to cognitive engagement and is inversely correlated with children’s average fear intensity. Effortful Control is generally not associated with cognitive engagement but is inversely related in one segment. 

Pamela Cole 16785
Representation and Responsive: An Example through Medicaid Eligibility James Gulla

My honors thesis is attempting to explain why there is variation of Medicaid eligibility limits across states, and why some states are more generous in covering economically disadvantaged citizens compared to others. My research deals with the ideas of representation and government responsiveness to the economically disadvantaged. It will look at explanatory variables of partisanship, women in the legislature, interest groups, and other factors that may explain Medicaid eligibility generosity.

Marie Hojnacki 15983
Resource Guide for Penn State Abington Students Melanie Boston

Abington campus has over 200 international students. Many second-year international students were remote the first year and are academically at risk. In addition to the challenges of transitioning from remote to in-person, they may have cultural and linguistic barriers. We created a printed resource to help students acclimate to campus and community resources. This visually appealing resource can transmit accurate information in a straightforward, timely manner without the need to navigate various webpages or emails.

 

Barry Bram 16692
Role of BAR protein Nwk in clathrin and gamma-tubulin localization Hannah Mirshahi and Ashlyn Soteres

Microtubules are essential for long-distance transport in neurons. Local microtubule production by nucleation particularly concentrates at dendritic branch points. To investigate why nucleation machinery concentrates at branch points, we used an RNAi knockdown approach to knock down nervous wreck (Nwk), a membrane curvature-recognizing protein, from Drosophila neurons. Nervous wreck knockdown showed no significant concentration change in clathrin nor gamma-tubulin, two proteins involved in nucleation, suggesting that nervous wreck is not essential for either protein’s localization.

Melissa Rolls 16819
Role of NusG in the regulation of pyr gene expression in B. subtilis Kunal Koka

Expression of the pyrimidine biosynthetic operon (pyr) in B. subtilis is modulated as a function of environmental pyrimidine conditions. Three attenuator regions alter expression of the pyr operon through a transcription attenuation mechanism. pyr repressor protein (PyrR) binding and stabilization of mRNA anti-antiterminator is essential for silencing of pyr expression. Previous RNET-seq data has identified NusG dependent pause sites in the attenuator regions of pyr, indicating potential involvement of NusG in regulation of pyr.

Paul Babitzke 17027
SAT solver with a Machine Learning Approach Arya Keni

Boolean satisfiability (or SAT problem) plays a key role in CS and in our many real-life applications. The most well-known algorithm of SAT problem is DPLL (Davis-Putnam-Logemann-Loveland), and people are trying to apply various kinds of Machine learning algorithms for optimizing problems. We investigated all ML algorithms on DPLL and found that some specific ML algorithms show more efficient results. Furthermore, applying Neural-Networks to determine Literal selection gives us an insight into Formal Hardware-Verification processes.

Mahfuza Farooque 16690
Screening for Traumatic Brain Injury Among Incarcerated Individuals via the ImPACT Quick Test Nicholas Glunt

Cognitive impairment and mental health problems are well documented within incarcerated populations. To identify affected inmates, a simple screening tool may be useful: the ImPACT Quick Test. 98 inmates without documented history of TBI participated. Study group ImPACT composite scores were significantly lower than the test’s normative population. This suggests that incarcerated individuals likely exhibit impaired cognitive performance when compared to non-incarcerated individuals, ultimately providing a link between inmates’ cognitive performance and mental health.

Nathan Kruis 16419
Seat Security and Tweet Extremity: An Analysis of Congress Members’ Tweets Emma Cohen

This study seeks to understand what factors drive extremity on social media using over 500,000 tweets from members of the 117th Congress. I predict that Congress members who are not confident in their ability to be reelected will appeal to the electorate through moderate tweeting and those who are secure have the option to be extreme in their tweeting. I implement a dictionary method to construct extremity scores and regress this on various potential influences.

Michael Berkman 16970
Second Year Engagement Program Rachel Zughaib et al

Poster presentation with accompanying audio narration describing how we used grant funding to enhance the second-year student experience.

Barry Bram 16832
Second Year Enhancement at Penn State DuBois Brittany Stanton and Colleen Lanzoni

This presentation will be on the success of the events/products that we used our Second Year Enhancement funding for. These include a Second-Year Specific Leadership Session with PSU Alum and Motivational Speaker, Rohan Murphy, a special second-year only Penn State giveaway at a Campus Counseling Coffee Talk event, and our Winterball event.  which was ramped up in 2022 for students who may not have had a prom experience due to the pandemic

Barry Bram 16508
Second Year Student Connections Kira Hamman

Penn State Mont Alto took a three-pronged approach to getting second-year students engaged on campus. In the Faculty Connections program, faculty take second-year students to lunch to build informal relationships outside the classroom. In the Advisor Connections program, students who meet with advisors receive bookstore gift cards. And in the Student Connections program, students participate in guided study groups in the second-year courses in our Nursing, Physical Therapy Assistant, and Occupational Therapy Assistant programs.

Barry Bram 16589
Second-Year Enhancement Program & Spanish at Berks Maria Fellie

I am a faculty memeber whose program received funding from the Second-Year Enhancement Program. I will share how we used the funds this past year in the First to Second Year Forum.

Barry Bram 16935
Second-Year Program Reflection: BYO Study Kit Megan Owens

Presentation covers purpose and outcomes of utilizing First to Second Year Task Force funding for BYO Study Kits. 

Megan Owens 16526
Second-Year Program Reflection: Second-Year Retreat at Shaver's Creek Megan Owens

Reflections and outcomes from utilizing funding from the First to Second Year Task force to create a half-day excursion to Shaver's Creek for HHD second-year students.

Megan Owens 16527
Self-Determination and Natural Resources Benjamin Lakavage

I am interested in explaining why self-determination movements succeed or fail, which various across individual self-determination movements. I expect that the variation in the success of self-determination movements results from control of natural resources such as diamonds and oil. I  expect to observe this relationship because natural resources can generate grievances, money and trade opportunities that can be used to aid self-determination movements.

Marie Hojnacki 16028
Sentencing Bias Against Lesbian and Gay Criminal Offenders Rae Griffith

          Sentencing bias has been explored for a myriad of factors such as race, sex, and mental health, but not for LGBTQ+ identity. Using a series of vignettes that address different crimes, this study seeks to identify any sentencing bias against lesbian and gay individuals. Results do not support the existence of such bias but do show higher recommended punitive sanctions against male offenders and against those with female victims.

Nathan; Nicholas Kruis; Rowland 16388
Social Media Usage Effect on Symptomatology for Those with Obsessive-Compulsive Brittany Bacorn

This randomized pre-test and post-test control group study investigates the impact of social media use on severity of obsessive-compulsive disorder (OCD).

4 participants assessed severity of OCD and reduced time (experimental group only) spent on social media for 14 days.

Analyzing with a paired-samples T test; Preliminary results suggest that social media use does not have an impact on symptoms of OCD. The findings can be used to manage social media use and OCD symptoms.

Yi-An Burleson 16900
Solving Differential Equations With Deep Neural Networks (DNNs) Jaysa Grafton

This project utilizes deep neural networks to solve the Poisson and Ginzburg-Landau equations. Results for the Poisson equation show an accurate solution is acquired using a single layer network with no activation function due to linearity. For the Ginzburg-Landau equation, two loss functions are utilized with adjustments being made for boundary conditions and derivatives. Results indicate an accurate approximation for various mesh sizes and allow for comparison of architectures to determine the optimal network parameters.

Leonid Berlyand 16658
sophoMORE program Janine Becker

The sophoMORE program supports second year students and retention providing a roadmap to guide students to best practice activities and support services in a fun and engaging way.  This may include study support, service, or alumni engagement, and career and social experiences.  For completing each item students will receive a stamp on their roadmap. At the end of the academic year students will receive a small token in recognition of their accomplishments.

Barry Bram 16671
State Capacity, Civil Society, and COVID-19 Caroline Camp

 Why are some countries more successful than others at responding to the COVID-19 pandemic? I expect that the variation in policy response is caused by both civil society and state capacity, especially the degree of involvement and activity of civil society and the state’s capacity for providing public goods, which also vary across countries. This paper seeks to analyze the effects of state capacity and civil society on the policy success: infection and death rates. 

Marie Hojnacki 15976
Stochastic Simulation of Tumor Relapse Suggest a Tradeoff in Evolutionary Trajectories Mengde Liu

Targeted therapies offer dramatic improvements in progression free survival (PFS) for some patients. However, most patients eventually fail targeted therapy due to the emergence of drug resistance. The major genetic mechanisms of this acquired resistance are point mutations and copy number amplifications of the target gene, or amplifications of a potent, off-target oncogene that bypasses the target oncogene. Using physical parameters acquired in previous studies, our simulation shows a tradeoff between these evolutionary trajectories.

Justin Pritchard 16852
Stories from Nurses on the Front Lines of the COVID-19 Pandemic Logan DeSanto

Background: Nurses have been exposed to challenging experiences while working throughout the COVID-19 pandemic. Purpose: To explore experiences of front-line nurses during the COVID-19 pandemic and feasilbility of story circles. Methods: A qualitative design using story circles and surveys to gather data. Results: Two themes were identified – navigating uncharted waters and persisting through COVID-19. Conclusions & Implications: Nurses are resilient and innovative; but, experienced changes in views of healthcare, the nursing profession, and communities. 

Michael Evans 16617
Stormwater Treatment using Biochar in Extreme Climate Events Mitchell Corsi

As extreme climate events become increasingly frequent across the state of Pennsylvania, it is absolutely imperative to manage stormwater diligently with water quality in mind, especially as the land becomes more urbanized. Stormwater hits roofs, roads, parking lots, lawns, industrial sites, and cropland, and becomes what is called stormwater runoff. Biochar is an emerging stormwater BMP (best management practice) that can help remove contaminants from stormwater runoff and improve the environmental conditions of Pennsylvania’s waterways.

Lauren McPhillips 16987
Strain Diversity of Biofilm Formation within the Multi-Strain Symbiosis of Vibrio fischeri and Euprymna scolopes Grace Buddle

Studying phenotypic differences of biofilm formation can grant insight into its role close organism interactions. Biofilms have been found to allow bacterial aggregation and initiate symbiosis. This is being investigated through the characterization of eleven V. fischeri strains isolated from the light organ of a wild-caught squid, following symbiosis establishment. Coevolved bacterial strains isolated from a single host likely exhibit different levels of biofilm formation that contribute to the dynamics of multi-strain symbioses.

Tim Miyashiro 16908
Strains of Vibrio Fischeri that Co-colonize Share Similar Growth Patterns Christina Beaubrun

          Vibrio fischeri is a light producing bacteria known to colonize a structure called the light organ of its squid host Euprymna Scolopes. Canonically, 5 to 6 different strains of V. fischrei will colonize an individual squid. Bacterial competition is a standard motif in microbiology so questions arise from this co-colonization of a host. How can 5 to 6 distinct strains survive in the same system? Bacterial growth patterns may help in answering this question.

Timothy Miyashiro 17026
Structure of the Numerical Semigroup Tree of Multiplicity 6 Jake Yuraszeck

A numerical semigroup S is a subset of the natural numbers (with 0) that satisfy two properties: there are a finite number of natural numbers that aren't in S, and the sum of any two numbers in S is in S. The set of all numerical semigroups can be organized in a tree structure based on their fundamental properties. We study the tree structure of numerical semigroups that have 6 as the smallest non-zero element.

Michael Steward 16918
Student Veterans Needs Survey Andrew Butch, Trevor Basham and Drake Collins

Being a student veteran comes with its own unique challenges and therefore requires a unique response. A needs assessment was sent out to everyone actively using veteran benefits on campus. A total of 72 participants completed the survey. Student veterans with the Douglas W. Pollock Center for Addiction Outreach and Research performed a reflexive thematic analysis. The themes generated were a desire for a streamlined process and desire for support and understanding from faculty.

Ovgu Kaynak 17086
Study of localized cooling of Photomultiplier Tubes using Thermoelectric Cooling Devices. Harshraj Bandyopadhyay

Photomultiplier-tubes work on the principle of the photoelectric effect and they can detect Cherenkov light.  However, PMT also produce background signals due to internal effects, called dark noise. Dark noise dominates the signal in any given PMT by several orders of magnitude, negatively affecting the ability of an array of photo-sensors to detect neutrinos. The dark noise rate is strongly dependent on the PMT's ambient temperature. A potential solution to this is thermoelectric coolers.

Douglas Cowen 16622
Subclinical Hypothyroidism is Associated with Dysregulated HPA-Axis Response to Stress in Otherwise Normal Healthy Volunteers Chloe Connor

Subclinical hypothyroidism is linked to poor health. The effects of subclinical hypothyroidism on cortisol reactivity stress was examined in 54 healthy men and women aged 18-30 years. Participants with elevated TSH levels displayed significantly higher baseline cortisol levels. Cortisol levels increased among participants with normal TSH levels but decreased in response to stress among participants with elevated TSH levels. This cortisol decrease reflects dysregulated HPA-axis functioning known to be associated with depression and cognitive dysfunction.

Laura Klein 16427
Surface Meltwater Lake Drainage Patterns at the Amery Ice Shelf Grounding Zone Anton Fatula

The goal of this project is to better understand and quantify the magnitude and frequency of surface meltwater lake drainages occurring across the grounding zone of the Amery ice shelf. Results from this project could help to define more clearly the role that meltwater plays in ice shelf stability for this and many other shelves buttressing the Antarctic Ice Sheet.

Luke Trusel 16849
Swine Production and Leaching in the Philippines Shreyas Sundar

Only second to rice, swine production accounts for a large portion of Filipino agriculture. Despite its potential benefits, one drawback of swine agriculture is that pig waste contributes to groundwater contamination through a process called leaching. Leaching occurs when contaminants are carried through particles of soil by water. This poster will use a systems thinking lens to review literature exploring the economic, social, and ecological impacts of leaching in Filipino swine agriculture.

Noel Habashy 16913
Temperament & Resting-State Brain Functional Connectivity in Rodent Model of Behavioral Inhibition Ritika Sagar and Shweta Marathe

In children, behavioral inhibition (i.e. avoidance of novelty) is a strong predictor of later anxiety disorders. Resting-state brain functional connectivity has been related to both behavioral inhibition and anxiety disorders. For example, in anxiety disorder, patients have decreased default mode network (DMN) and fronto-parietal network (FPN) connectivity – two systems associated with emotion regulation and cognitive control. In this study, we examined whether a rodent model of BI shows similar altered DMN/FPN connectivity.

Sonia Cavigelli 17145
The Association Between Adult Attachment Style and the Therapeutic Alliance: A Meta-Analytic Study Rachel Blansfield

A meta-analysis was conducted to determine the association between adult attachment style and the therapeutic alliance. A random-effects model was used to determine the mean product-moment correlation (r) for 15 studies. The mean weighted r for avoidance and alliance was -.19, 95% CI [-.28, - .11]. The mean weighted r for anxiety and alliance was -.16, 95% CI [-.23 to -.09]. The implications for future research and clinical applications will be discussed.

Kenneth Levy 16513
The Danger of Being Anesthetized While Female: The Common Use of Unconsented Pelvic Exams as Teaching Practice Constitutes Unethical Assault on and Objectification of Patients Priya Devanarayan

For decades, female patients undergoing anesthesia have commonly been subject to unrelated, unnecessary, undisclosed, and unconsented pelvic exams in teaching hospitals—violating both medical ethics and personal rights. Despite growing attention to the unethical and legally questionable nature of this practice, only a third of states have adopted legislation requiring explicit consent. Increased awareness and legal mandates necessitating explicit informed consent must be adopted to force teaching hospital compliance with the ethics they proclaim to instill.

Michele Mekel 16796
The effect of ICTs on Protest Success Brendan Teufel

I will be presenting my thesis research on the effects of cell phones and internet on the success of protest. I will be conducting a regression on a few hundred country years with a number of control variables including whether a country is a fuel dependent economy, and whether a country has presidential elections. 

Joseph Wright 16027
The effect of parasitic wasp (Aphidius colemani) odor cues on nymph production and host-plant selection of aphids (Myzus persicae). Thomas Thomas

Aphids are major pests of a variety of crops. One-way aphid populations are controlled is by using their natural predators and parasitoids. However, the mere risk of predation induces changes in behavior that influences herbivore success. Prior work has shown odor cues of predator insects influences aphid movement and reproductive capacity. In this study, we tested whether odor cues of a different natural enemy, parasitic wasps, also influences aphid host-plant selection and nymph production.

Sara Hermann 16975
The effect of physical activity and energy restriction on tumor hypoxia and blood vessel normalization in a triple negative breast cancer model Abriana Cain

Developing strategies to prevent metastatic disease is key to reducing mortality from breast cancer. Gene expression and immunohistochemistry were used to quantify hypoxia and vessel normalization within the tumors of physically active and energy restricted mice. Only the combination of physical activity and energy restriction significantly reduced gene expression of HIF-1α in the tumor microenvironment of this metastatic breast cancer model. Quantification of vessel normalization is in progress.

Connie Rogers 17001
The Effect of Stress on Opioid Use Behaviors: A Review of Preclinical Literature Geneva Flarend

Opioid misuse is a critical public health crisis in the United States that results in over 50,000 deaths per year. Stress is considered a key risk factor for addiction developent, inspriring this review which examines how stressful experiences throughout the lifespan alter opioid use in animals. The findings suggest that neonatal or adult stress increases addiction-like behaviors in rodent models, but that adolescent social stress may protect against later opioid misuse, which contradicts human studies.

Helen Kamens 16978
The effect of y14 on aggregates formed by Huntington's Disease Esha Kunshetty

This study focuses on an RNA-binding motif protein 8A gene (RBM8A), or y14, and its effect on gene regulation in Huntington’s Disease.  y14 functions at the protein level to correct and degrade misfolded proteins; it is possible that y14, when overexpressed, can reduce the aggregates formed in patient brains. We will test the effect of y14 on aggregates formed by Huntington’s disease both in vitro and in vivo to determine its potential uses for treatment. 

 

Yingwei Mao 17077
The Effectiveness of Gender Equality Quotas and their Impact on Women’s Representation and Participation in Politics in Francophone Nations Allison Zajac

Gender equality quotas exist in most of the world's legislatures in some capacity in an effort to increase women's political representation. While representation has increased in recent years, it is unclear whether or not quotas have an effect on women's political participation in their home countries. This project attempts to analyze the relationship between quotas and political participation among women.

Sona Golder 16782
The Effects of Art and Therapy on Physical and Psychological Healing Megan Brennan

Art and therapy can reduce stress to promote mental and physical healing. I analyzed studies with data on the effects of art in medical settings. There was healing in all settings for patients regardless of gender, age, or illness. My project was nature-inspired coloring pages for any patient. Ideally, the use of these coloring pages in medical settings will help to lessen both mental and physical symptoms of stress for their users.

Ana Patricia Aguilera Hermida 16774
The Effects of Engaging Vaccine Misinformation via Social Media on Mental Health Colton Walters et al

Medical misinformation is a contributing factor in the decline of global vaccination acceptance. This between-group repeated measures manipulation study attempted to investigate whether a relationship exists between vaccine misinformation and positive and negative affect. The hypothesis was that engagement with vaccine misinformation found on social media led to increased negative emotions and decreased positive emotions when controlling for overall stress, anxiety, and depression levels in emerging adults. The results did not present any significant relationships.

Melanie Hetzel-Riggin 16889