2024 Undergraduate Exhibition

Title Presenter Abstract Faculty Sponsor Numbersort ascending
Surveillance for influenza A virus antibodies in wild canids in Pennsylvania Kaitlyn Bahrs

Since 1996, goose Guangdong lineage H5 highly pathogenic influenza A viruses (HPIAV) have caused a panzootic with significant impacts on poultry and wild birds. In December 2021, subclade 2.3.4.4b H5N1 HPIAV spread throughout North America, where atypical detections of fatal H5N1 HPIAV infections have been recorded in wild mammals. The goal of this study is to determine the seroprevalence of H5N1 IAV in wild canids in Pennsylvania before and after HPIAV introduction.

Justin Brown 53
A High-Throughput Computational Pipeline that Identifies Active, Small Self-Cleaving Ribozymes Riddled with Imperfections Benjamin Chang

Twister, twister sister, and hammerhead are small self-cleaving ribozymes that cleave their phosphodiester backbone and are defined by unique structures. By combining multiple RNA computational tools with customized scripts, I created a pipeline capable of searching through numerous genomes for these three ribozymes simultaneously. We identified over 800 novel ribozyme candidates in over 50 organisms. From these, we experimentally tested our top candidates and confirmed the first active twister ribozyme in a mammal, the dolphin.

Philip Bevilacqua 52
The Impact of Peer Group Size on Adolescent Socially Risky Decision-Making Behavior Tess Leonard

Adolescence demonstrates a dynamic time where young people risk interacting with new social groups.It is unknown whether the number of peers present increases the experience of rejection or elicits differing decisions to interact. The present study investigates how adolescents differ in their risk-taking behavior between social and non-social environments, how behaviors differ as a function of peer group sizes, and how risk taking in a laboratory task relates to real-world risk taking.

Nina Lauharatanahirun 51
Integration Investigation: Feeding Regime Alters Patterns of Integration in Cichlids Alexandra Kwiatkowski

The Amazonian cichlid Satanoperca displays the unique behavior of winnowing, feeding by swallowing and sifting mouthfuls of sediment to reveal food. Sediment type appears to affect their foraging and swimming behaviors. We investigated several key traits involved in swimming mechanics in Satanoperca to test their capabilities for plastic response in various sediment types. We found significant differences in mean shape among treatments groups for various skeletal traits, which reveals their integrative and modular nature.

Thomas Stewart 50
Senators & Social Media: How Social Media Usage Effects Electoral Success Alianne Crockett

My project explores the connection between senators' use of Twitter/X as a form of communication and their electoral success. I am looking at Twitter/X data on incumbents from 2013-2015 and categorizing the incumbents into different styles of communicators based on their tweeting styles. I correlate that with the electoral results of the 2014 and 2016 elections to asses which styles of communication may be the most successful for incumbents and those seeking election to adopt.

Marie Hojnacki 5
Senior Thesis: Association Between False Memories and Creativity Among Older and Younger Adults Andrea John

The dynamics between creativity and false memories are poorly understood. This study aimed to explore this phenomenon by observing semantic false association performance with age as a modifier. Younger adults (N=172) and older adults (N=124) completed the Category Fluency, generating as many clothing items as possible within a time limit. Findings indicate no significant effect of semantic false associations on creativity performance across age. Future research is needed to understand the mechanisms underlying this.

Nancy Dennis 49
Prevalence of non-exclusive breastfeeding in the context of vitamin D supplementation during pregnancy and lactation in Bangladesh. Sarah Scott

Vitamin D deficiency, a global health issue, may impact lactation by modulating mammary inflammation and lipid metabolism. In this study, we aimed to examine the impact of vitamin D supplementation on exclusive breastfeeding prevalence during early infancy. We found that the relative prevalence of non-exclusive breastfeeding was lower in early infancy among mothers receiving vitamin D supplements during pregnancy and lactation compared to placebo, but results were inconsistent across supplementation dosage groups.

Alison Gernand 48
Core-shell commensal biocapsules for in situ gut microbiome engineering Sonika Kohli

The human microbiome harbors commensal bacteria essential for bodily function. Current broad-spectrum antibiotics disrupt microbiome balance, rendering the body vulnerable. To address this, peptide-carbohydrate biocapsules were fabricated. These biocapsules are loaded with commensal bacteria and feature an antimicrobial coating, exhibiting potential to re-engineer the microbiome instead of disrupting it. The biocapsules target pathogenic growth while selectively releasing beneficial bacteria at infection sites. This biomaterial could revolutionize microbiome interventions, laying the foundation for broader health benefits.

Scott Medina 47
Mastering the Material: Factors Influencing Content Retention Andrew Graham and Alexa Verkuilen

Wonder if students remember what they learn? We predicted content retention using a few key predictors: number of credits concurrent with course, interest, final grade, and instructor feedback. We had also considered engagement and social identities, but these were not significant. In sum, motivating and inspiring interest should be a priority for instructors for content retention long-term. Grades, while influential as a marker for retention, are not as important as increasing intrinsic motivation for learning.

Dustin Elliott 46
Investigating the effects of H1N1 influenza infection on mRNA expression of vitamin D metabolism genes in lungs Nicholas Hanna and Suzanne Kozloski

Vitamin D (VD) protects mice from severe influenza infection. We examined how VD metabolism genes, Cyp27b1, Cyp24a1, and the vitamin D receptor (VDR), were affected by influenza infection. Results showed that Cyp27b1 and VDR mRNA in the lung were not different throughout infection. Conversely, Cyp24a1 mRNA expression was significantly increased (P<0.05) at day 6 post-infection, suggesting increased VD metabolism in the lung. This result supports the importance of VD in the host response to influenza.

Margherita T. Cantorna 45
Optimizing Prebiotic Conditions for Non-enzymatic RNA Synthesis of Complex RNAs From Smaller RNAs Parker Wood

RNA is believed to be a key precursor to life, yet the conditions for its transition into a genetic molecule and catalytic unit remain unknown. Here we show that low concentrations of divalent cations and carboxyl-containing organics are likely contributors to increased RNA complexity. These findings support further research with varying organics and divalent cation concentrations. This work has the potential to unveil new insight on the origins of life on Earth and extrasolar bodies.

Philip Bevilacqua 44
The effect of social media on mental health Viktoriia Viktoriia

Previous research shows a link between social media and poorer mental health among young people. Studies link the use of social media with depression, anxiety, insomnia, stress, eating disorders, fear of missing out. The project will involve in-depth interviews and quantitative surveys with college students recruited from Penn State Berks to explore thoughts, decisions, and reflections about their experiences with social media. 

Ada Leung 43
'Examining the physical, social, and risk-related consequences of alcohol use as predictors of alcohol use disorder symptoms among college students' Alyssa Altstaedter et al

College students' alcohol use is a public health concern with physical, social, and risk-related consequences. Consequences like hangovers, unwanted sexual situations, and embarrassing oneself may be associated with alcohol use disorder (AUD) symptoms. Electronic surveys spanning six weekends assessed college students' (N= 462, 51.7% female, 87.7% White, Mage= 20.1) drinking behaviors and consequences. This project uses linear regression analysis to examine the extent to which alcohol-related consequences are associated with AUD symptoms among college students.

Robert Turrisi 42
Effect of down-regulation of a putative feruloyl transferase gene on plant growth and lignification. Katie Martell

Feruloyl transferase is theorized to play a role in the transport of ferulic acid to the cell wall and the subsequent formation of a dimer between ferulic acid and arabinoxylans. This creates a site for the bonding of lignin to the cell wall which reinforces the cell's structure and contricutes to the plant's rigidity.

Marcia Buanafina 41
Can a person anticipate what will happen next in English sentences during adverse conditions? Yaquelyn Rivera and McKenzie Waslosky

One way that humans can comprehend sentences is by anticipating or predicting upcoming words in the sentence. The present study builds on these findings to explore how people listen to and comprehend English sentences under conditions of babble versus silent background conditions using eye-tracking. Results show that under adverse speaking conditions, listeners find it more difficult to make predictions about upcoming input.

Carrie Jackson 40
Characterization and Bioinformatic Analysis of Related Vibriophages with ~42,000 bp Genomes from Chesapeake Bay Emily Barrett

Vibriophage are viruses that infect the marine bacterium Vibrio harveyi. A new cluster of vibriophages, Cluster B, were isolated from Chesapeake Bay oysters. These vibriophage are characterized by their shorter genome of ~42,000 bp, in comparison to the previously characterized Cluster A, which have genome lengths of ~126,000 bp. The genomes of these vibriophage were sequences and compared, and the lytic and lysogenic properties were analyzed.

Gregory Broussard 4
Semi-automated Fabrication of Atomically Sharp Tips Baird Bankovic

Here, I made an easy-to-use semi-automated machine (Zyrus) that fabricates atomically sharp tips repeatably. It does so by chemically etching tungsten wire, until the submerged portion breaks off. To avoid blunting the tip, etching needs to be terminated as quickly as possible. Zyrus monitors the etching current, and automatically terminates the etching once the current falls below a threshold. Zyrus can reliably produce tips with an effective radius of < 50nm.

Nitin Samarth 39
Adenlyosuccinate alleviates mobility deficits associated with Adenylosuccinate Synthetase deficiency in Caenorhabditis elegans Melinda Jin and Rishika Patil

ADSSL1-Myopathy is an ultra-rare muscular disorder caused by a mutation in the purine nucleotide cycle (PNC) gene, ADSSL1. ADSSL1-Myopathy had been hard to characterize on a molecular level due to a lack of adequate models for its study. We are investigating the functions of ADSS using C. elegans and are exploring the use of PNC substrates as a potential therapy. We have established movement phenotypes associated with ADSS function that can be rescued by adenylosuccinate.

Wendy Hanna-Rose 38
Unitization in a Free Recall Task Micaela Tovar

Unitization is a memory support that allows words pairs to resemble single items (Carpenter & Dennis, 2023). However, there is limited work comparing single items to unitization, especially in a free recall task. A free recall task could determine if unitization functions like an item in situations where there are not external cues involved. This study aims to address if unitized words are recalled more similarly to single items or associations in a recall task.  

Nancy Dennis 37
Evaluating the mismatch hypothesis: An analysis of the evolutionary history of Type II Diabetes Lauren Heverly

Evolutionary mismatch is a mechanism whereby disease-associated genetic variants that experienced positive natural selection in past environments because they were beneficial to fitness, may now contribute to negative health consequences in the context of present, modern environments. This project investigates the plausibility of the mismatch hypothesis for Type II Diabetes (T2D) by integrating genome-wide association data for individuals with South Asian ancestry (n=40,850) and evolutionary genomics.

George Perry 36
The Effect of Life History Theory on Attraction and Relationship Satisfaction Samantha Sibold

This project seeks to find the effect of life history theory on attraction. Participants were asked to answer self-report questions to measure their perceived childhood adversity and SDT Traits in order to distinguish their life history strategy. The hypotheses tested were 1) individuals will more often be attracted to people they perceive to align with their life history strategy and 2) slow strategist couples will have higher relationship satisfaction compared to fast strategist couples. 

Alicia Drais-Parrillo 35
Renewable Chemoenzymatic Synthesis of Substituted Alkenes and 3-Hydroxypropionate Using the Ethylene Forming Enzyme (EFE) Yash Satyendra Dixit

Ethylene Forming Enzyme (EFE) is a iron (II) and 2-oxoglutarate dependent enzyme that can produce the compound ethylene as well as trace amounts of 3-hydroxypropionate, a valuable chemical building block with potential to synthesize biodegradable plastics. Our project seeks to perform protein engineering of EFE by amino acid substitutions in the substrate binding pocket such that 3HP is the primary enzymatic product, and also modify the 2-oxoglutarate substrate to synthesize substituted alkenes through the enzyme.

J. Martin Bollinger Jr. 34
Identifying Inter-Strain Competition Dynamics Between Vibrio fischeri Symbionts Catelyn Carter and Kaitlyn McKelvey

Robust microbiomes are often shaped by symbiotic host-microbe relationships. Multi-strain symbioses forming when multiple strains of the same bacterium successfully colonize a host are prevalent in animal-microbe relationships, but certain molecular mechanisms influencing microbial competition during their establishment remain poorly understood. This research seeks to characterize interactions between three co-isolated strains of bioluminescent marine bacterium Vibrio fischeri in vitro, revealing more about factors underlying the formation of multi-strain symbioses in similar model systems.

Timothy Miyshiro 33
SEXUAL AND GENDER MINORITY COLLEGE STUDENT DISPARITIES IN BIOBEHAVIORAL HEALTH OUTCOMES Jordan Yerger

More college students than ever identify as sexual and/or gender minorities (SGM), but health disparity research is lacking for this population. Biobehavioral health outcomes were examined among SGM college students (n=445) and cisgender heterosexual peers (n=2867). SGM students were younger, reported more stress and depression, less happiness, poorer sleep quality, and drank less alcohol than their peers (p's<0.05). Groups were similar in body mass index, GPA, and daily nicotine use. Health implications will be discussed.

Laura Cousino Klein 32
Gut Feelings: Understanding the Role of Bacteriophage in Modulating the Gut Heejung Koo

The gut microbiome hosts a wide range of microbes that affect our health. Understanding community dynamics is a key way to understand infectious diseases and how the gut microbiome can positively or negatively affect our overall health. However, an important part of this community is rather unknown. Bacteriophages are viruses in microbial communities that target bacteria. Understanding how bacteriophages shape community structure and function will allow us to understand the holistic picture regarding the microbiome. 

Jordan Bisanz 31
Integrating Drawing and Mindfulness to Reduce Anxiety in Adolescents: A Pilot Feasibility Study Margaret Penner

Anxiety symptom onset peaks in adolescence (Essua et al., 2018). Mindfulness meditation has been shown to reduce anxiety (Keng et al., 2011), yet benefits may be diminished due to difficulty maintaining engagement (Lymeus et al., 2019). This study of 84 adolescents used a novel drawing-based intervention integrating an approachable and tangible activity with mindfulness elements. Initial results indicated that this guided drawing intervention bolstered physiological emotion regulation and reduced anxiety symptoms. Next steps include comparing the guided drawing intervention with free drawing and simple drawing control conditions.

Sarah Myruski 30
Religious Governmental Integration and Gendered Violence Riley Gallagher

I have investigated the relationship between religious integration in government and gendered violence. In order to control for religious differences, I have limited this study to only include Islam. My study includes 59 countries with a baseline Muslim population of 20%. Islamic religious integration includes constitutional references to Islam, religious political parties, and sharia based law. I hypothesize that with greater religious integration there will be more gendered violence. 

Lee Ann Banaszak 3
Modified Acoustic Plethysmograph for use with 2 Photon Microscope Brett Westgate

This open-source acoustic plethysmograph generates thermal imaging of a mouse’s breath and volumetric data of the respiration volume of the mouse inside. This plethysmograph can also be used with a 2-photon microscope to generate neural imaging of the mouse while inside the vessel. The whole device is controlled through LabView and allows for user input to change the inner volume of the vessel or the outputting frequency to adjust the resulting resonance frequency.

Patrick Drew 29
Verification of Injection Sites in Support of Chemogenetic Experiments Testing Brain Substrates of Stress Resilience Sabrina Elduff

Investigation of the stereotaxic injection sites in mouse brains that were chemogenetically manipulated to reveal the brain substrates for stress resilience.

Bernhard Luscher 28
Molecular Characterization of Bacillus licheniformis Isolated from Milk Samples Victoria Hoelzle

A study was done to characterize both the phenotype and genotype of 36 Bacillus isolates. These isolates were obtained from mixed culture samples of clinical Bovine mastitis milk. Next-generation sequencing revealed that B.licheniformis encoded for the lipopeptide lichenysin A and the synthetase genes lchAA, lchAB, and lchAC for lichenysin. Preliminary observations suggest that B. licheniformis is an environmental mastitis pathogen, warranting further investigation into its potential to cause intramammary infections.

Jayarao Bhushan 27
Analysis of Reversal Learning in Bluebirds Gabriel Casanova

Learning flexibility is vital to overcome challenges for survival. My experiment tested the learning flexibility in Bluebirds through a reversal learning puzzle by using a wooden trapdoor lever mechanism; switching the active lever’s location between left and right.  I used BORIS software to measure the frequency and length of different bluebird and nestbox interactions. Information from analysis will help demonstrate the Bluebird’s environmental adaptability.

Jason Keagy 26
The Connection Between Noise Pollution, Personality, and Bird Cognition Caitlin Honus

We do not currently understand if there is a correlation between noise pollution and cognition and how individual personality is involved. Eastern bluebirds were exposed to gas compressor noise while performing a cognitive task. Subsequent analysis of behavioral trials quantified personality traits, including neophobia, activity, persistence, and exploration. Anthropogenic noises are prevalent in the environment and may have a significant impact on the reproductive success of Eastern bluebirds.

Jason Keagy 25
Determining a Genetic Basis for Male Stickleback Fish Brain Size David Fleck and Yun Chen Liu

Brain size is widely variable among species, but its genetic basis is not well-understood. Stickleback fish brain images from an F2 generation of 80 males (descended from populations with different brain sizes) were measured for whole and regional brain size. Fiji software was used to conduct the measurements, which will be added to a previous sample of 80 brains to enhance the understanding of the genetic basis for brain size.

Jason Keagy 24
Evaluating the Efficiency of trans-Translation Inhibitors in Pathogenic Bacteria. Leila Lipscomb

The emergence “superbugsâ€

Kenneth Keiler 232
Isolation and Characterization of the Globin CoupledSensor Proteins Noah Brady

Globin-coupled sensor proteins are a family of multidomain proteins which link sensory input to a diverse array of downstream effectors. The extremophile Thermus aquaticus encodes a GCS protein (TaqGCS) with putative diguanylate cyclase activity, which has not been isolated or characterized to date. AfGcHk was also purified to compare the mechanism of signal transduction between GCS proteins. Discovering unique proteins across the GCS family can further elucidate their role in sensory perception and signal transduction.

Emily Weinert 231
One World - Original Song Rohit Valecha

From the expanse of the universe to the cell that brings all life to earth, oneness is what we come together for. We sow the seeds of solidarity for a world we imagine and propagate the change, within and beyond us. We stand tall as a kindled conscience that aches at the sound of violence and pushes us in being kindred spirits in practicing radical empathy. Here's celebrating our togetherness- One World.

Laura Spielvogel 230
Characterizing in vitro Competition Between Strains of Vibrio fischeri Cameron Murray

Microbial communities have major impacts on the health of their host, but the process of microbiome assembly is not yet understood. The symbiosis between Vibrio fischeri and Euprymna scolopes is an excellent model for microbiome assembly.  The role of competition in community establishment was tested in this project through competitive assays between Vibrio fischeri ES114 and five novel strains isolated from wild squid. These competitions will inform further studies of virulence factors in community establishment.

Tim Miyashiro 23
Modeling the interaction of genetics and competition in black walnut (Juglans nigra) populations growing in a provenance trial Laurie Enders

Genetic variation across species ranges and along climate gradients shows that forest tree populations can adapt to their home climate. Of interest in our study is modeling the interaction of genetics and competition in black walnut (Juglans nigra) populations growing in a provenance trial at Penn State. Understanding how genetics and competition interact is critical to improving seed transfer guidelines, seed orchard design, and how tree species respond to a changing climate.

Laura Leites 229
EXPLORING CHARACTERISTICS OF SYMPATHETIC SOLAR FLARES Abishek Judah Mohan, Joshua Parfitt and Yeganeh Abdollahinejad

This study examines 2203 sympathetic flares from the Sympathetic solar flare (1975-2017) catalogue on the Harvard Dataverse. We analyze key timestamps—start time, peak time, and end time—to delineate the rising and decay phases of these flares. Our findings reveal a correlation between flare duration and the duration of their rising and decay phases, with longer-duration flares exhibiting extended phases. A frequency distribution analysis demonstrates a predominance of shorter-lived flares. We also observe asymmetry in the duration of rising versus decay phases, with the majority of sympathetic flares showing a longer decay phase. Investigation into the change in latitude over the solar cycle indicates a transition from a dispersed distribution to an alignment with the solar equator, particularly evident around 1985, 1995, and 2005. Notably, most sympathetic flares occur within 30 degrees of the solar equator. This study provides valuable insights into the behavior and characteristics of sympathetic flares, contributing to our overall understanding of solar dynamics.

Asif ud-Doula 228
The Relationship between Gut Microbiome Diversity and Levels of Blood Glucose and Hematocrit in Birds Lisa Wang

The gut microbiome is known to harbor commensal bacteria crucial to maintaining host homeostasis, physiology, and health. With growing emphasis on birds as at-risk indicator species and sequencing technology advancements, research is necessary and possible for understanding how changes in the avian gut microbiota impact metabolic pathways. Here, we investigate the relationship between gut microbial diversity (16S fecal metabarcoding) and plasma blood glucose/hematocrit levels in Eastern Bluebirds and Tree Swallows captured in central PA.

David Toews 227
Link between NADK gene variants and VACTERL association. Chihaorui Zhang

Our work explores the functional connection between inhibition of NAD kinase (NADK) expression and congenital malformations using the nematode model C. elegans. We will use RNAi to knock down NADK to test the hypothesis that inhibition of this gene results in congenital malformations and changes the trajectory of aging in this model. These studies will provide insight into the association between NADK inhibition and congenital malformations as well as the impact of malformations on aging.

Melanie McReynolds 226
How do forest temperatures influence eastern box turtle (Terrapene carolina carolina) movement patterns? Taylor Balint

Eastern box turtles (Terrapene carolina carolina) have declined across their Pennsylvania range in recent years due to environmental disturbances and are a species of special concern. The objective of this study is to understand how forest temperatures influence behavior in these turtles through the analysis of thermal data gathered from weekly radio telemetry surveys. The results from this study will provide valuable information for land managers to help create suitable habitat for this species. 

Julian Avery 225
Effects of GART Knockdown on Healthy versus ADSL Mutant Caenorhabditis elegans. Abigayle Nafus

F38B6.4 is the C. elegans ortholog to the human gene GART, involved in three steps of purine metabolism. Adenylosuccinate lyase, or ADSL, deficiency is a rare purine metabolism disorder that presents in nematodes as decreased size and speed, as well as irregular movement. RNAi techniques were used to knockdown GART expression in mutant worms already deficient in ADSL to measure the phenotypic changes in the animal.

Wendy Hanna Rose 224
The Effects of Audio-Visual Stimuli on the Memory of Dementia Patients Carolina Hernandez

The present study tested the effects of audio-visual stimuli on the memory of dementia patients further expanding on research conducted by Baird, et al. (2018). Overall, it consisted of two sessions where the participants were randomly divided into a control group (only pictures) and an experimental group (picture and song together). The first session stimuli was based on the reminiscence bump, with the second session stimuli using preferred music genre and a personal picture.

Cobi Michael 223
Violations of Kepler's Third Law Among Exoplanet Types Sadid Hassan and CJ Dunham

Currently, exoplanets are classified into four differentcategories based on their size: terrestrial, super-earth, Neptunian, andGas Giants. According to Kepler’s Third Law of planetary motion, thesquares of the orbital periods of these planets are directlyproportional to the cubes of the semi-major axes of their orbits. Thepurpose of this research is to investigate whether this law alwaysapplies to each category of exoplanets. If not, the research aims tounderstand the factors that could cause a divergence from therelationship, and whether those differences are a trend in thatparticular exoplanet type. It is expected that exoplanetary systems willfollow Kepler’s Third Law if: 1. the exoplanets are much less massivethan the parent star, 2. gravitational influence between the planets isnot significant, 3. the stellar system is clear of dust and debris, and4. the system does not contain multiple stars. Our preliminary resultsshow that there are several systems of exoplanets that deviate from suchKepler’s Third Law with majority being among the terrestrial type.Further, this research aims to explore the factors that could cause thisshift, whether it be experimental errors or the existence of a hiddencelestial body in the planetary system influencing the orbit of aparticular planet.

Asif ud-Doula and Gillian Pearce 222
Investigating regulation of the stability of SLF proteins involved in self-incompatibility in Petunia inflata Natalie Babitzke

Petunia inflata utilizes self-incompatibility (SI) to prevent self-fertilization and consequent inbreeding. S-Locus F-box (SLF) proteins control pollen function in SI. Each SLF is part of the SCFSLF complex that contains either PiCUL1-P, or PiCUL1-B, as the CUL subunit. I found that the level of a GFP-fused SLF protein in mutants with both CUL1 genes knocked out was extremely low, suggesting that the integrity of the SCFSLF complex is essential for the stability of SLF proteins.

Teh-hui Kao 221
Optimizing selectable marker systems for Agrobacterium-mediated transformation of Theobroma cacao Emilio Ciervo

The Theobroma cacao tree, used to make chocolate, struggles with diseases: a problem that could be alleviated through breeding for new varieties. As a tropical tree crop, its long time to maturity and limited geographic range restrict breeding efforts. Genetic engineering could be a faster approach, although current protocols using the Agrobacterium-mediated transformation method have low efficiencies. This project aims to optimize the existing protocol by comparing ptxD and SulR to nptII as selectable marker genes for transformed cells.

Siela Maximova 220
Electrochemical C-H Activation of 2-Naphthol Jessica Frangiosa

The overall goal of this project was to expand on pre-existing work published regarding the coupling of biaryl molecules. The main publication that was expanded on involved carbon-carbon coupling and cross-coupling reactions in order to synthesize symmetrical and non-symmetrical biaryl molecules, respectively. The desire to synthesize biaryl products stems from their applications in molecular catalysis, and materials science. These applications stem from the fact that these products can be chiral ligands. Chiral ligands are important in the synthesis of other molecules because in order to synthesize a chiral molecule, chirality in the starting material is required. In the context of BINOL, which is mainly considered in this work, the chirality that this compound possesses is called axial chirality.

Eric Nacsa 22
Investigating effects of Passive Integrative Transponders (PIT) tags on body condition of red-backed salamanders (Plethodon cinereus) in Central Pennsylvania Samantha Bryn

Red-backed salamanders (Plethodon cinereus) are one of the most common salamander species in Pennsylvania. Passive Integrative Transponders (PIT) tags are a promising way to individually mark animals for long-term studies. This research estimates body condition between PIT tagged and untagged populations of P. cinereus. We did not find any negative effects from the presence of a PIT tag on individual body condition; this relationship was true for both males and females. 

Maisie MacKnight 219
Age-Specific Effects of NAD+ Precursors on Vitality in Caenorhabditis elegans Shaina Johnson

Nicotinamide Adenine Dinucleotide (NAD+), is an essential coenzyme to key metabolic pathway and declines with age. This phenomenon is associated with various hallmarks of aging and raises questions about supplementing declining NAD+ levels. Although NAD+ precursor supplementation has become popular in recent years, its impact remains poorly understood. Thus, this study investigates the impact of two NAD+ precursors that drive NAD+ synthesis in C. elegans: Nicotinic Acid (NA) and Nicotinamide (NAM). 

Melanie McReynolds 218

Pages