In neurons, microtubule polarity enables differentiation between axons and dendrites and promotes proper cell function. There are several known mechanisms that regulate polarity in dendrites, yet mechanisms at the cell body and their contribution to the cell's overall polarity are not fully understood. TRIM 9 proves to be a positive regulator of plus-end out neuronal processes, promoting the hypothesis of a relationship between the regulation and establishment of microtubule polarity at cell body exit points.