Characterizing the differences between the volatile organic compounds produced by healthy and diseased blood may enhance our understanding of the body's health-state on decompositional processes. Headspace solid-phase microextraction paired with gas chromatography-mass spectrometry was used for the detection of volatile emissions of nondiseased and diseased blood, specifically anemic and diabetic blood. VOCs were collected at 5 different time intervals via SPME fiber headspace. Throughout this research, diseased and nondiseased blood VOC profiles consistently differ.