Many cancers exhibit changes in lipid metabolism and expression of CD36, a key mediator of fatty acid uptake. Our group explored whether CD36-mediated fatty acid uptake could promote EMT, which is implicated in cancer progression.  We hypothesized that CD36 overexpression and oleic acid treatment would promote EMT by inducing lipid droplet formation and downregulating E-cadherin expression. We find that doxycycline-inducible CD36 overexpression and oleic acid increase lipid droplet formation while decreasing E-cadherin expression.