In neurons, intracellular trafficking, signaling, and cell structure depend on microtubules (MTs), which are also thought to play key roles in the development of neurodegenerative disease. Since they work with MTs during mitosis, we suspect spindle matrix (SM) proteins may regulate microtubules at steady state and in repair. Using an injury assay to trigger upregulated microtubules and genetic tools such as RNAi, I investigate communication pathways between MTs and SM proteins across the nuclear envelope.?