With the widespread use of Histidine-Rich Protein (Hrp)-sensitive rapid diagnostic tests for malaria, some strains of P. falciparum have mutated gene deletions for hrp2, the gene encoding for Hrp. Strains with hrp2 gene deletions are unable to be diagnosed through these tests, a phenomenon known as diagnostic resistance. Through mathematical models of malaria disease progression and population level simulations, the factors contributing to the widespread evolution of diagnostic resistance were determined.