According to the CDC, approximately 122,000 Americans die each year due from lodged thromboemboli that are unable to be cleared following acute ischemic stroke.  Despite this, there is a lack of research on what thromboemboli properties affect the success of re-canalization and patient outcomes. An ex vivo circulatory loop, incorporating an excised bovine artery and a programmable centrifugal pump, will be developed to simulate physiological cerebral flow conditions and investigate thromboemboli lodging and adhesion.