Stress increases the risk of Major Depressive Disorder. We used a mouse model in which SST+ cells were rendered hyperactive (SSTCre:γ2f/f mice), causing the mice to display an antidepressant phenotype, to study how activity of SST+ cells affects chronic stress-induced depressive behaviors. We quantified SST+ cells, which in control mice have been shown to be reduced by stress. We predict that SSTCre:γ2f/f mice are resilient to chronic stress-induced depressive behaviors and loss of SST+ cells.