Antibiotic resistance is an urgent global threat resulting in millions of infections and thousands of deaths in the United States alone. This is a consequence of common drugs becoming ineffective against various bacterial pathogens such as M. tuberculosis. Inhibitors of trans-translation, a novel target pathway, have been identified through a high-throughput screen of a 13,000-compound library.  Consequently, the active compound KKL-4669 is the current focus of pre-clinical tests involving various fluorescent and biochemical assays.