Casey M Carr
This study attempts to understand the effect of vitamin D on placental angiogenesis. Placental tissue samples (n=80) were obtained after delivery from a randomized, dose-ranging, placebo-controlled trial of maternal vitamin D supplementation with four groups. Angiogenic outcomes, terminal villi count, density, area, and VEGF expression, were quantified using ImageJ. Analysis shows vitamin D supplementation compared to placebo did not have a significant effect on any of the angiogenic outcomes.