Stress erythropoiesis is a process that the body utilizes to maintain homeostasis under stress conditions caused by anemia. Fetal hematopoiesis utilizes the Lin28b-let-7-Hmga2 axis to produce erythrocytes in a way that is similar to stress erythropoiesis. I hypothesized that the HMGA2 gene is upregulated during stress erythropoiesis as part of the Lin28b-let-7-Hmga2 axis in order to maintain homeostatic concentrations of oxygen in systemic tissue. HMGA2 targeted gene therapy may be the key to treating anemia.