Developmental stress increases invertebrate octopamine(OA) production which blocks serotonin(5-HT), which can have long-lasting behavioral consequences. To study the effects of starvation on neurotransmission in arachnid Parasteatoda tepidariorum, paralogs of OA and 5-HT synthesizing enzymes and receptors were identified using BLAST of spider transcriptome. Results showed ptDBH and ptTPH expressed through development. RT-PCR revealed 5-HT and OA receptor orthologs are differentially expressed throughout development with some sex bias. Spiders can starve ~30 days before death.