In this work, we provide a detailed examination of the correlation between MR-DTI changes and mechanical strain using an experimental and computational investigation approach. The research is classified into a three-step process which consists of 1) pre-imaging the sample of interest 2) impose a mechanical strain on the sample to cause deformation and rupture of the fibers in the sample and 3) obtain a post-MR-DTI image of the sample to observe changes in FA.