Sensitive measures of structural changes, due to brain injury detected with fractional anisotropy (FA), show conflicting trends in how FA changes due to injury. In this work, we provide a detailed examination of the correlation between MR-DTI changes and mechanical strain using an experimental and computational investigation approach. This presentation will focus on the MR-DTI data, mechanical testing and finite element simulation that have been conducted to correlate mechanical strain with changes in fractional anisotropy.