A specific globin coupled sensor (GCS) found in Pectobacterium carotovorum subsp carotovorum ("PccGCS") has been found to affect the motility and virulence of this plant pathogen. Through a bioinformatic approach, the role of globin coupled sensor signaling in motility was investigated. This approach compiled the use of genome neighborhood and sequence conservation analyses, molecular modeling and protein-protein docking simulations. As a result, the motility-related protein CheW was identified as having potential to bind PccGCS.