This work presents the results of a noninvasive three-dimensional (3D) full-field mechanical measurement of shoulder bones under different loading conditions. Micro X-ray Computed Tomography (µ-XCT) of the specimen is taken under no-load and loaded conditions. Then a glenoid implant is cemented into the specimen by a shoulder surgeon. µ-XCT of implant-bone structure is taken under no-load and loaded conditions.The deformation and strain in bone with or without implant under various loading conditions are compared.