Assessing the Chemo-Mechanical Properties of Cytoplasmic Dynein through In Vitro Assays

by Thomas R. Blanda
Molecular motors are implicated in a myriad of transport phenomena crucial to the cell's maintenance of vesicle translocation and cell division. A fortified understanding of the underlying mechanisms that drive these motors to bind microtubules and traverse along them can provide insight into neurological diseases like Alzheimer's and Parkinson's. The primary objective of this study was to determine chemical and mechanical parameters of cytoplasmic dynein (DDB) using motility assays with mixed molecular motors.
Major: 
Biomedical Engineering
Exhibition Category: 
Engineering
Exhibition Format: 
Poster Presentation
Campus: 
University Park
Faculty Sponsor: 
William O. Hancock, Professor, Chair of the Intercollege Graduate Program in Bioengineering
Poster Number: 
259