Characterization and Target Identification of Hydrazine Carbonothiol Inhibitors

Antibiotic resistance is a growing global epidemic. New antibiotics must be developed to combat this problem. The hydrazine carbonothiol compounds target the trans-translation pathway in bacteria and are a promising and novel class of drugs. This research aims to characterize the properties of the hydrazine carbonothiol compounds and identify the target within the trans-translation pathway. This facilitates further modifications to the compounds to maximize therapeutic value during antibiotic development.