Donor organs can’t meet demand, but tissue-engineered alternatives are not yet feasible to treat some of the worst chronic diseases or traumatic situations. Thus, there is a need for developing new biomaterials that will make cost-effective, non-immunogenic, and prolific tissue-engineered constructs a possibility. Pelodiscus sinensis collagen could be one such material but has not been characterized in this context. Here, we examine antioxidant activity of and cellular response to this novel collagen.