Neurons are polarized cells that are susceptible to injury due to neurotoxicity from stroke, seizure or traumatic brain injury. Previous work has demonstrated that the DLK signaling pathway, while required for axon regeneration, is dispensable for dendrite regeneration. mthl3, a member of the methuselah/methuselah-like family of GPCR, was identified as a gene required for dendrite regeneration in a functional genomics screen. The goal is to determine the specificity of mthl3 in dendrite development and regeneration.