The role that iron plays in affective outcomes is not well studied in women of reproductive age. The hypothesis is that iron supplementation will improve overall mood and quality of life and decrease feelings of stress compared to placebo. Participants recruited from Penn State were categorized as iron depleted or sufficient. Iron treatment improved feelings of Physical and Social Functioning and decreased feelings of Bodily Pain, Stress, Tension, Anger, Depression, Confusion and Total Mood Disturbance.