Coacervates are spontaneously-formed polymer-rich liquid droplets.  They tend to concentrate biomolecules including RNA and so present an attractive system for the origins of protocells and membraneless organelles. We found that RNA aptamers retain function in coacervates, indicating that the native fold of the aptamer is maintained. At increasing temperatures specific coacervates can destabilize RNA aptamers. We are utilizing chemical probes to detect RNA structural changes due to coacervates.