Gamma delta T cells are a subset of T cells that lack conventional major mistocompatibility (MHC) requirements that for the response to self-like antigens such as tumor metabolites and stress-related proteins. These innate-like cells largely reside in epithelial tissues such as the epidermis, suggesting that they may be relevant in the formation of squamous cell tumors. We show here that gamma delta T cells respond to these tumors through effector molecules IL-17 and Interferon-gamma.