Identification of trans-Translation Inhibitor Antibiotics

Antibiotic resistance has become a clinical threat in recent years due to mass usage of antibiotics and evolving genetic mutations. One molecular pathway not targeted by current antibiotics is the trans-translation pathway. The Keiler Lab screened a 13,000-compound library. Various assays are currently testing potential inhibitory compounds from this screen confirming their activity against trans-translation. Consequently, the goal is to develop novel antibiotics void of pre-existing resistant mechanisms to combat this phenomenon of resistance.