This study examined cardiometabolic risk in college students (n=5,986) by fitness level and obesity status. Our study showed significant differences in cardiometabolic risk factors by quartiles of fitness and obesity status. Higher fitness was associated with reduced rates of dyslipidemia (β=0.94,p<0.000), prediabetes (β=0.97,p<0.000) and hypertension in males (β=0.93,p<0.000) and prediabetes (β=0.97,p=0.04) and hypertension (β=0.93,p<0.000) in females. In males and females, obesity was associated with higher rates of dyslipidemia (β=1.15,p<0.000), prediabetes, (β=1.06,p<0.000) and hypertension (β=1.14,p<0.000).