Drug delivery methods often suffer from problems ranging from pain and patient noncompliance to reduced drug bioactivity. A series of in-vitro assessments were performed to determine the mechanical strength, insertion ability, encapsulation efficiency, and bioactivity of polymer microneedles containing the model protein VEGF. In-vivo assessments were performed using live mice. The ability to control the release of bioactive proteins through the skin may provide revolutionary new treatments for a range of different pathologies.