ChIP-exo is one of the most precise high-throughput technology to map protein-binding detection. However, each ChIP-exp experiment is noisy and has complicated patterns. Measuring the reproducibility of ChIP-exo replicate experiments ensures the reliability of downstream analysis. To assess the reproducibility, our group developed a novel statistical method based on a technique in time series analysis. The method is effective in differentiating signals with different quality. Dr. Qunhua Li and Tao Yang mentored this project.