Antibiotic resistance is a growing issue that leads to the ineffectiveness of drugs that treat bacterial infections. New investigations are currently underway to determine the effectiveness of helper compounds, which include a range of drug classes, particularly antihistamines. Antihistamines oppose the constitutive activity of histamine receptors, which function to produce biological responses. The antihistamine, Azelastine, possesses antibacterial activity by altering bacterial membrane permeability.