Macrophages, cells of the immune system, play a pivotal role in the host inflammatory response by attacking foreign materials not seen as ‘self.’  Implanted biomedical devices made of polyurethane are not identified as ‘self.’  The potential of coating polyurethane with ‘self-like’ molecules to reduce or prevent the host response from attacking such devices propelled this research. The reduction of macrophage adherence to polyurethane films coated with palmitoleic acid and bovine serum albumin will be presented.