Chromatin remodelers are highly-conserved eukaryotic protein complexes which package and modify DNA. One such complex, SWI/SNF, is mutated in 20% of human cancers. To characterize select mutations we analyzed purified SWI/SNF from six strains of SWI/SNF mutant yeast. Using assays targeting the binding, ATP hydrolysis, and nucleosome mobilization of the complex, we found that four mutants displayed severe loss of function, one had mild loss of function, and one had no loss of function.