Activity of Tetrazole-based trans-Translation Inhibitors in Bacillus anthracis

by Emily C Snell

With the rapid development of antibiotics came an era of pathogenic bacteria that evolved resistance. This is motive for exploration of an alternative protein control pathway that can be targeted for antibiotic development and surmount these multi-drug resistant pathogens. The pathway exploited in this investigation is trans-translation. My research initiates the investigation of the tetrazole class, which inhibit this pathway. Major methodology includes MIC, CFU/mL, endospore germination, cytotoxicity assay, and growth curve.

Major: 
Microbiology
Exhibition Category: 
Health and Life Sciences
Exhibition Format: 
Poster Presentation
Campus: 
University Park
Faculty Sponsor: 
Kenneth Keiler
Location: 
Alumni Hall, HUB-Robeson Center
Poster Number: 
177