This study investigated whether chronic adolescent social stress, genetic background, and their interaction influence later morphine sensitivity and sensitization. Our data show that genetic background alters morphine responses such that C57BL/6J mice developed a sensitized response to morphine, but BALB/cJ mice did not. Further, in C57BL/6J mice, adolescent social stress attenuated morphine sensitization. Our findings suggest that adolescent stress interacts with genetic background to alter behaviors related to opioid dependence.
Adolescent social stress and genetic background alter morphine sensitization in C57BL/6J and BALB/cJ mice.
by Aidan James Peat
Social and Behavioral Sciences
Alumni Hall, HUB-Robeson Center