by Brandon Park
RNA Polymerase II (Pol II) clustering is emerging as a regulatory step in transcription. Using Drosophila nurse cells, which contain gigantic Pol II clusters, we discovered that these clusters colocalize with certain transcription factors. They contain Pol II molecules that are phosphorylated on Ser5 and Ser7, but not on Ser2, suggesting that the Pol II clusters do not reside on active loci. Starvation of Drosophila results in altered clustering patterns, suggesting that clustering is regulated.
Biochemistry and Molecular Biology
Health and Life Sciences
Alumni Hall, HUB-Robeson Center