Antibiotic resistance is an urgent global threat resulting in millions of infections and thousands of deaths in the United States alone. This is a consequence of common drugs becoming ineffective against various bacterial pathogens such as M. tuberculosis. Inhibitors of trans-translation, a novel target pathway, have been identified through a high-throughput screen of a 13,000-compound library. Consequently, the active compound KKL-4669 is the current focus of pre-clinical tests involving various fluorescent and biochemical assays.
Characterization of KKL-4669: Identified Inhibitor of trans-Translation
by Alexis Marie Davison
Biochemistry and Molecular Biology
Health and Life Sciences
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