Plasmodium parasites are the causative agent of malaria.These parasites contain a conserved tudor staphylococcal nuclease (TSN) whose function is not well understood; our lab has previously demonstrated that PyTSN1 interacts with translational repressors involved in the preparation of parasites for transmission to mosquitoes. To better characterize this protein, I have generated three transgenic parasite lines to identify function, localization, and protein-protein interactions of PyTSN1 through gene deletion, tagging, and proteomic approaches.
Characterization of Plasmodium yoelii Tudor Staphylococcal Nuclease, PyTSN1
by Olivia Margaret Smith and Erin Cover
Health and Life Sciences
Alumni Hall, HUB-Robeson Center