Characterizing Cytotoxicity and Inflammation in Silica-induced, RAW264.7 Macrophages In-vitro.

by Jessica Rodriguez
Crystalline silica (cSiO2) has been found to be a toxic trigger for autoimmune diseases, such as lupus, when inhaled for an extended period of time. The cSiO2 is phagocytosed, causing the release of cytokines and eventually cell death. In order to examine this pathway in-vitro, RAW264.7 macrophages were stimulated by lipopolysaccharides before the cytotoxicity was measured through a lactate dehydrogenase (LDH) assay. Through the LDH assay, a dose-dependent cSiO2 toxicity was observed.
Major: 
Toxicology
Exhibition Category: 
Health and Life Sciences
Exhibition Format: 
Poster Presentation
Campus: 
University Park
Faculty Sponsor: 
Josephine Wee
Location: 
Alumni Hall, HUB-Robeson Center
Poster Number: 
156