Development of Inhibitors of the SigmaE Pathway in E. coli Bacteria

Matthew Kostelac

The rise of antibiotic resistant bacteria stands to become a major threat to public health in the future, and new novel antibiotics are more important than ever as a result. In order to develop such a novel antibiotic, I am attempting to optimize a compound known to weakly inhibit the SigmaE pathway, an important stress-response pathway in Gram-negative bacteria. Upon developing enough compounds, they will be evaluated for effectives using a previously-developed reporter assay.
Major: 
Biochemistry and Molecular Biology with Molecular and Cell Biology Option
Exhibition Category: 
Health and Life Sciences
Exhibition Format: 
Poster Presentation
Campus: 
University Park
Faculty Sponsor: 
Kenneth Keiler
Location: 
Alumni Hall, HUB-Robeson Center
Poster Number: 
185