Stress increases risk of developing Major Depressive Disorder. The brains of mice subjected to six weeks of Unpredictable Chronic Mild Stress (UCMS) show a reduced density of somatostatin immuno-positive cells. We are comparing the density of genetically labeled somatostatin cells and the density of somatostatin immuno-positive cells between UCMS mice and UCMS mice that underwent six weeks of recovery. We predict that the density of somatostatin immuno-positive cells returns to baseline after recovery from stress.