The SAGA complex is a multi-functional protein complex involved in transcriptional regulation and histone modification, particularly under stress. Notably the SAGA complex has been linked to development of certain neurodegenerative diseases and cancers. To better characterize SAGA’s ability to regulate gene expression under various stressors, I analyzed SAGA’s binding characteristics under two conditions: subunit knockouts and heat shock. These analyses resulted in a clearer picture of SAGA’s regulatory role under different conditions of stress.