Inflammation associated with allergic asthma is often controlled with inhaled corticosteroids (ICS). Here, we used an allergic asthma mouse model to study ICS’s effects on anxiety-like physiology and behavior. We measured corticosterone levels in serum and feces, and we measured anxiety-like behavior on the elevated plus maze in mice treated chronically with house dust mite allergen and ICS. Our results showed that there was a negative relationship between the doses of ICS and anxiety-like behavior.