Lipopeptisomes: Anticancer Peptide-assembled Particles for Fusolytic Oncotherapy

Matthew Ross Aronson

Anticancer peptides (ACPs) are naturally occurring molecules that preferentially kill cancer cells. Although ACPs represent attractive new drugs, their clinical utility is limited by severe side-effects. Here, we exploit the interactions of ACPs with cancer cell membranes to prepare a new class of membrane-mimetic ACP nanoparticles, referred to as a lipopeptisome (LP). We show that LPs potently destroy cancer cells without significant damage to healthy tissues, thus transforming previously toxic drugs into clinically viable therapies.

Major: 
Biomedical Engineering
Exhibition Category: 
Engineering
Exhibition Format: 
Poster Presentation
Campus: 
University Park
Faculty Sponsor: 
Scott Medina
Location: 
Alumni Hall, HUB-Robeson Center
Poster Number: 
114