Antibiotic resistance is a growing problem. The trans-translation pathway is a new drug target for the discovery of novel antimicrobials. A screen for antibiotic activity and inhibition of the trans-translation pathway was conducted with natural products extracted from marine plant life in Hawaii. Identified hits were found to inhibit growth of pathogens, including Bacillus anthracis,as well as target the trans-translation pathway. Hits will be characterized to determine the mechanism of action.