Streptomyces is a genus of Gram-positive bacteria, an important attribute of Streptomyces is its ability to produce secondary metabolites with bioactive properties including antibacterial compounds. Whole genomic sequencing has identified silent gene clusters encoding for secondary metabolites of unknown biological activity. CRISPR editing is used to tie secondary metabolite synthesis to primary metabolite production and induce expression of silent gene clusters. The suppressor mutants created are sequenced to identify what mutations allow this to happen.