by Melissa Long and Abigail Mauger
Neurons are exposed to a variety of stressors, resulting in axon injury and neurodegenerative disease. Using Drosophila as a model, we aim to better understand how neurons respond to axon injury, which could further knowledge of these disease mechanisms and aid in treatment development. Chordotonal neurons, a ciliated sensory cell, must regenerate axons differently than dendritic arborization neurons. Wnt molecules secreted by epithelial cells are potential ligands that initiate gtubulin localization at dendritic branchpoints.
Immunology and Infectious Disease
Health and Life Sciences