Acculturation and discrimination are risk factors for alcohol-related consequences among Hispanics, but it is unknown how the two interact. This study examined whether discrimination moderated the association between acculturation and consequences in Hispanic college students (N=245). Students attending three large public universities completed surveys during years two (T2) and four (T4). Discrimination moderated the association between T2 acculturation and T4 consequences. Results inform how culturally-specific risk factors interact to affect alcohol consequences among Hispanic students.