Elk K+ channels form a functionally distinct subfamily of ether-à-go-go (Eag) channels; a class of tetrameric, voltage-gated channels that are conserved in both Drosophila and mammals (1). Elks are believed to regulate the firing threshold of neurons and prevent hyperexcitability that leads to epileptic activity (2). This project investigates the relationship between the voltage sensor and channel pore in order to develop a greater understanding of ion channel biophysics and voltage sensing.