Sepsis occurs when the immune system responds to an infection in the bloodstream; this often leads to organ damage, organ failure, and death. Successful treatment of sepsis relies on rapid diagnosis of bloodstream pathogens. Current diagnostics techniques, however, prove inefficient and have not been optimized for low bacterial concentrations. This project aims to develop a rapid, clinically relevant diagnostic technique for sepsis in order to improve clinical diagnostics of blood-borne pathogens.