Catalytically-active single-chain polymer nanoparticles (SCNPs) seek to resolve the issues of toxicity and recyclability associated with traditional methods. SCNPs draw inspiration from enzymes, specifically the idea of a catalytic compartmentalization. These nanoparticles can be formed by attachment of dipyrrin ligands (DPY) to a polymer backbone followed by crosslinking via metal ligation. Four DPYs were successfully synthesized for incorporation onto polymers. When successfully crosslinked, the SCNPs will be used to target cross-coupling reactions.